Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season, is becoming more of a friend to Monk as the series develops, frequently calling him in to help, as much for Monk's benefit as for his own. However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective."
Despite flaws and inadequacies all around, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant. From the double-episode pilot through the first half of season three, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk," as she still addresses her new boss.
剧情介绍：
妻子的死让警探艾德里安（托尼·夏尔赫布 Tony Shalhoub 饰）的生活跌落到了谷底，不久之后，经常堕入悲哀之中的艾德里安患上了强迫症，强迫症令艾德里安在警局里无处容身，很快，他便丢掉了任务，成为了无业游民，
为了生活，艾德里安必需赚钱，就这样，一家公家侦探所成立了，艾德里安雇佣了护士莎罗纳（Bitty Schram 饰）为他打理日常生活，本人则靠着出色的逻辑推理才能和过目不忘的神奇身手处理了一件又一件新奇案件，之后，艾德里安结识了名为娜塔莉（特蕾勒·霍华德 Traylor Howard 饰）的独身母亲，两人之间非常投缘，随着工夫的推移，丧妻之痛由浓转淡，但妻子被害一案的来龙去脉却仍然深藏在迷雾之中，艾德里安可以依托本人的力气破解此案揭开心结吗？
